Insane Medicine, Chapter 8: Treatment Traps and How to Get Out of Them (Part 2)


Editor’s Note: Over the course of several months, Mad in America has published a serialized version of Sami Timimi’s book, Insane Medicine. This is the final chapter. In Part 1, he discussed deconstructing diagnosis, the nature of psychological injury, and how identifying a problem can become a self-fulfilling prophecy. In Part 2, he discusses working with medication and coming off medication. All chapters are archived here.

Working with medication

You may have gathered by now that I am not a great fan of psychiatric medication (also known as psychotropic medication). For many decades doctors have not been able to use them with a proper understanding of their limitations. They end up being used for too long at too high a dose and with too many people.

We have been trained in a way that ends up with us doctors using them rather liberally, but have not been trained in how to see their use within the broader context of a person’s life—nor have we been trained in how to help people come off them.

We also belong to systems that encourage us to feel that we should have to offer something concrete to our patients (like a prescription). Furthermore, our patients are in a culture that trains them to imagine that mental suffering has no meaning and can be eliminated with McDonaldised remedies. Such supply and demand characteristics have led to the massive over-use of psychotropic medications, which is one of the biggest contributors to the awful outcomes and reduced life expectancy for those who become long-term mental health patients.

That doesn’t mean medications can’t be helpful for some people at some points, particularly when used for shorter-term interventions. Whilst most of my practice related to medication involves helping someone reduce or completely withdraw from psychotropic medicines prescribed originally by someone else, there are also occasions where I am the person who initiates the prescription. This can be to help keep a therapeutic alliance going, because of understandable pressure from a young person and/or their family, or because I suggest it.

Below are some of the contexts that I keep in mind when working with these psychiatric medications:

  • Diagnoses in psychiatry are not diagnoses – they are poor descriptors and do not explain.
  • Likewise, psychiatric medications have no disease-specific effects – there is no such thing as an “anti-depressant,” “anti-psychotic,” “mood stabiliser,” and so on.
  • Psychotropic medications, like alcohol or street drugs, stimulate or depress certain neurotransmitters and have general effects on our mental state as a result.
  • They cause chemical changes/imbalances rather than remedy any chemical imbalance.
  • The resulting altered mental state that a psychiatric drug produces can help a person cope with a situation or improve a situation in the short-term.
  • There is little evidence to suggest any psychotropic medication leads to sustained improved long-term outcomes.
  • All psychoactive substances can produce tolerance if taken for long enough. In everyday language this means that they can all be addictive and cause withdrawal symptoms if stopped suddenly.

This backdrop helps orientate me to what I need to keep in mind when working with individuals taking psychiatric medication and their families. Given that most of the drug effect is imitated by a placebo pill, the narrative we use when we prescribe has a much bigger impact on how the patient then experiences what happens to them than the chemical effects of the drug itself. These are aspects of prescribing that doctors like myself have had to figure out for ourselves, as we are not taught this.

The main story I use for prescribing psychotropics is that they are “enablers” that create windows of opportunity. I remind patients that a drug cannot make a decision or initiate an action; it is people who do that. I explain that psychiatric drugs work like any substance that affects our nervous system chemicals.

They don’t correct any chemical imbalance. No one can find any evidence that what we call mental disorders are the result of a chemical imbalance. Like alcohol, psychiatric drugs make you feel a little different and that can be useful in the short-term. For example, alcohol might help you overcome your shyness with others, but most of us would agree that using alcohol long-term for that can lead to all sorts of problems. This means the drug works best when we take advantage of feeling a little bit different to make what changes we can.

I use analogies to help the narrative along. If I’m hoping the drug will have a more activating, energising effect for someone who is withdrawn, I might use an analogy such as “It’s like some oil that helps our cogs turn more freely again. The cogs are you and it’s you that will be the one that then drives the change, not the drugs.” If I’m hoping for a more calming effect I might use an analogy like, “We have many interventions in medicine that don’t act directly on the problem. For example, a plaster cast around an arm with a broken bone has no direct effect on the bone, it just helps the bone stay still so that the body can do its natural process to heal the bone.

These ways of conceptualising the work of the drug helps prepare a person for their active participation as an agent in the healing process and gives a basis for helping them understand why they are likely to only need the medicine short-term, for say 6 to 12 months, and then they can be gradually weaned off.

Once the person has agreed to this framework you can help them develop that agency using a simple visualisation. This is known as the “miracle question.” When we are weighed down with a problem, we tend to focus on how that problem is dominating and making our life worse. Understandably we think that for life to improve we have to get rid or eliminate that problem.

Sadly, most treatments that subscribe to the belief that it is a specific treatment for a specific diagnosis reinforce this idea. The “miracle question” instead helps you imagine what you would want to see happening if the problem was less dominant. It helps you focus your efforts away from getting rid of something toward what you hope for instead.

Thus, as a way of introducing patient agency, I might ask something like this,

Consider I had the perfect prescription to give, only this is so good that all you had to do is take it once before you go to bed tonight. While you’re asleep this medicine works its magic, so that by the morning this miracle has happened and all that you hoped would change has changed. Because this miracle happened while you were asleep you don’t realise that the change has happened. What might you notice that might first alert you that something seems different? What might others who know you notice? What might you do differently?

You can then walk them through their day, taking care to help them move from the absence of negatives and generalisations to the presence of specific behaviours. For instance, “So you’d feel happier. I see, can you describe what I would see you doing if you were feeling happier?” and “So if you weren’t losing your temper, what would you be doing instead?” and so on. This helps the person start visualising the alternative, hoped-for future.

This should give you a list of different behaviours that they imagined they would do. You can now help them by introducing another concept: It’s not unusual that we try to do too much too quickly when we want to get rid of a problem. We wake up in the morning on some days and say to ourselves, “Right, I’m going to do this and that and the other today, no more moping about, fresh start, I have to change.

We keep things going for a bit, but crash within a few hours or the next day. This just reinforces our feeling toward the problem that it’s too strong for us and we cannot defeat it or get on top of it. Hopelessness enters and breeds on our feelings of failure.

Better to focus on small changes that are concrete and easier to notice. You can ask the person to pick one of the behaviours in their miracle list that might be a starting place that they would like to focus on making a small, tiny, barely noticeable change in, if the medication helped them feel a little freer.

I also note any example of functioning they were able to do already despite how they feel as in, “How did you still manage to take your child to school despite how you feel? That’s what we call resilience, still functioning in spite of how we feel. You’re clearly a resilient person.

You might also, instead of a specific behaviour goal, just ask them to notice difference, and that can be their goal. For example, “I’d like you to make a note, mental or written, of anything, however small or temporary, that is a moment where you felt just a little bit better, something was different, you did something however small you haven’t done for a while, whatever it is. Note it down because I’ll ask you about this next time we meet.

This is another way of helping the person start notice the presence of something rather than the absence of something.

It can also be useful to help that person think about their social support network. Supportive relationships can be vital for recovery. It’s as simple as enquiring about who else is there who can support them and in what way. “Who knows about what you’re going through? Who would you like to know about what you’re going through? How many of them might join a meeting or two with us?” And so on.

In follow up meetings, I try to help the patient recognise that they and their supporters are the agents of change. I search for examples they provide that suggest something different has happened, whether or not they report any change in the goal they set and whether or not they noted anything different.

If you listen closely enough there is usually something different that can be noticed. I never accept any inference that the medication has been the agent of change. I will remind the patient that medication doesn’t think and can’t make decisions.

I may ask them something like, “what qualities in yourself has medication helped you reconnect with?” and then we can spend time talking about this quality (for example, determination, courage, patience, kindness etc.) and how this quality coming alive again is playing out and may continue to develop over coming weeks. This helps patients reconnect with their inner resources and the resilience that has been there, if a bit dormant, all along.

Coming off psychiatric medications


Unfortunately, good professional advice from doctors is thin on the ground because of the very little training or knowledge that we have about withdrawing from psychiatric medication. My approach comes from a mixture of clinical experience, academic sources, and listening to the experience of those who have had problems withdrawing from psychiatric medication.

When weaning off any psychiatric medication, you should bear in mind that some withdrawal symptoms are likely. This is because psychiatric medicines act at the nerve endings of brain cells, and the result of their action is to increase or decrease the amount of a certain chemical involved in relaying signals from one brain cell to another (a neurotransmitter).

What often then happens after a while of this change in the amount of neurotransmitter is that brain cells start changing to adjust to the new levels of that neurotransmitter. For example, if a drug has caused an increase in neurotransmitter levels, then, over time, the brain cell receiving this neurotransmitter will start reducing the number of receptors (that receive the signal from this neurotransmitter) that it has, in reaction to the increase in this chemical.

This is why, for many people, the psychological effects of psychiatric drugs tend to wear off over time, often leading to gradually increasing doses being given. It also means that withdrawing the drug suddenly, going “cold turkey,” is not recommended.

My general rule of thumb is that if you’ve been taking a psychiatric drug for more than a couple of months then wean off gradually over a period of months, with gradually decreasing doses. The longer you’ve been taking the medication, the longer the withdrawal period may need to be.

Remember, withdrawal symptoms can easily be confused with the original problem and typically include feelings of anxiety, agitation, restlessness, confusion, and difficulty sleeping, but sometimes also include physical symptoms such as feeling like you have the flu, muscle pain and tremors, fatigue, as well as shocks often referred to as “brain shakes” or “brain zaps.”

However, frank withdrawal symptoms can appear randomly sometimes with sudden severe waves and windows when the patient otherwise feels relatively well.

Survivors of psychiatric medication are often the best sources of wisdom on this issue. The following are three online resources that I have found helpful and informative:

There are also some books that help with coming off medication, such as renowned researcher Peter Gøtzsche’s 2020 book Mental Health Survival Kit and Withdrawal from Psychiatric Drugs.

Here are a few pointers that may help:

    • Talk about it openly. Be prepared to be flexible in the withdrawal regimen.
    • Wherever possible, work with a health professional, preferably (but not necessarily) a doctor, who understands withdrawal phenomena and can help you recognize and manage withdrawal symptoms and possible drug interactions.
    • Involve trusted and supportive people in your social network in the discussions and decisions you take. Letting people know what you’re doing and finding out in what way they might be able to support you can be vital.
    • If anyone has been on the psychotropic for less than two months it may be possible to withdraw fairly quickly over a matter of a few weeks, although even after a few weeks on a drug, some may still experience withdrawal symptoms.
    • The general rule for reducing likelihood of withdrawal symptoms is little (small reductions) and slow (over an extended period).
    • For those taking the psychotropic for more than a couple of months then plan a careful staged withdrawal that can last for months, or even years. The longer you have taken the psychotropic the longer the withdrawal phase may need to be. If you experience any withdrawal symptoms after any reduction then you may wish to go back to the previous dose for a while longer before attempting a reduction again. Generally work with 10% reductions in dose each time you reduce, although you can make larger reductions at the higher doses and may need smaller reductions at the lower doses.
    • As a general principle only make the next reduction in daily dose when any withdrawal symptoms have stabilized.
    • Longer half-life (such as a few days—you can look up half-lives of drugs on google) drugs tend to cause less withdrawal symptoms than shorter half-life drugs.
    • When dealing with what we call “polypharmacy,” which is where someone is taking more than one psychotropic medication, leave more sedative ones or drugs prescribed for side effects of the other ones till later in the withdrawal programme.
    • Because of the way psychotropic drugs act on receptors in brain cells, you are much more likely to get withdrawal symptoms as you wean off the lower doses. If someone starts experiencing withdrawal symptoms at the lowest doses, try proceeding in roughly 10% reduction of dose steps—meaning you might have to go to very small doses. This may mean cutting tablets, or taking apart capsules and using sensitive scales to weigh amounts, although if a liquid preparation is available this makes doing these tiny steps much easier.
    • It’s sensible to avoid significant transitions/life events and have a relatively stable life situation when withdrawing.
    • Be aware of the nocebo effect (opposite of placebo effect—meaning the patient expects bad things to happen and so looks for confirmation that bad things are happening). Remember that drugs do not have agency; they do not think or make decisions.
    • Be aware of other psychological effects. As someone comes off psychiatric drugs, they will experience their emotions in a way they haven’t for a long time. This can be exhilarating, terrifying, or both, not just to them, but to those around them.
    • I strongly recommend not withdrawing without friend and/or family support.


    Reference sources

    Anda, R.F., Whitfield, C.L., Felitti, V.J., et al. (2002) Adverse childhood experiences, alcoholic parents, and later risk of alcoholism and depression. Psychiatric Services, 53, 1001-1009.

    Chapman, D.P., Whitfield, C.L., Felitti, V.J., Dube, S.R., Edwards, V.J., Anda, R.F. (2004) Adverse childhood experiences and the risk of depressive disorders in adulthood. Journal of Affective Disorders, 82, 217-225.

    de Shazer, S. (1985) Keys to Solution in Brief Therapy. Norton.

    Dong, M., Anda, R.F., Dube, S.R., Giles, W.H., Felitti, V.J. (2003) The relationship of exposure to childhood sexual abuse to other forms of abuse, neglect and household dysfunction during childhood. Child Abuse and Neglect, 27, 625-639.

    Dube, S.R., Anda, R.F., Felitti, V.J., Chapman, D., Williamson, D.F., Giles, W.H. (2001) Childhood abuse, household dysfunction and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study. Journal of the American Medical Association, 286, 3089-3096.

    Dube, S.R., Felitti, V.J., Dong, M., Giles, W.H., Anda, R.F. (2003) The impact of adverse childhood experiences on health problems: evidence from four birth cohorts dating back to 1900. Preventative Medicine, 37, 268-277.

    Dube, S.R., Anda, R.F., Felitti, V.J., Edwards, V.J., Williamson, D.F. (2002) Exposure to abuse, neglect and household dysfunction among adults who witnessed intimate partner violence as children: Implications for health and social services. Violence and Victims, 17, 3-17.

    Dube, S.R., Anda, R.F., Whitfield, C.L., et al. (2005) Long-term consequences of childhood sexual abuse by gender of victim. American Journal of Preventative Medicine, 27, 430-438.

    Haley, J. (1973) Uncommon Therapy: The Psychiatric Techniques of Milton H. Erickson, MD. Norton.

    Jackson, D.D. (1957) The question of family homeostasis. Psychiatric Quarterly Supplement, 31, 79-90.

    Johnstone, L., Boyle, M., Cromby, J., et al. (2018) The Power Threat Meaning Framework: Towards the Identification of Patterns in Emotional Distress, Unusual Experiences and Troubled or Troubling Behaviour, as an Alternative to Functional Psychiatric Diagnosis. British Psychological Society.

    Kendall-Tackett, K. (ed.) (2003) Victimization and Health. American Psychological Association.

    Luhrmann, T.M., Padmavati, R., Tharoor, H., Osei, A. (2015) Differences in voice-hearing experiences of people with psychosis in the USA, India and Ghana: interview-based study. British Journal of Psychiatry, 206, 41-44.

    McNamee, S., Gergen, K., (eds.) (1992) Social Construction and the Therapeutic Process. Sage Publications.

    Parks, J., Svendsen, D., Singer, P., Foti, M.E. (eds.) (2006) Morbidity and Mortality in People with Serious Mental Illness. National Association of State Mental Health Program Directors (NASMHPD) Medical Directors Council.

    Satir, V. (1964) Conjoint Family Therapy. Science & Behavior Books.

    Watzlawick, P., Weakland, J., Fisch, R. (1974) Change: Principles of Problem Formation and Problem Resolution. Norton.

    White, M., Epston, D. (1990) Narrative Means to Therapeutic Ends. Norton Press.

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James Barnes is a psychotherapist, lecturer and writer, with a background in post-Freudian psychoanalysis and philosophy. His core interests are in relational, intersubjective models of psyche and the de-medicalizing of emotional and psychological distress. He has a psychotherapy practice in Exeter, UK, and also sees clients remotely. He is currently writing a book on the relational psyche for Confer Books. You can follow him on twitter: @psychgeist52